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Elevating Urology Through Clinical Research

Conducting clinical research keeps us at the forefront of urology treatment and gives our patients access to promising treatments and expert knowledge. This research enables us to offer our patients in Philadelphia and surrounding counties the latest advancements in treatments.

Each clinical research trial follows strict guidelines to protect participants. Ask your doctor if there’s a trial that is right for you. Or call our Clinical Research Department at 610-667-0458.

Sponsors and CROs: Learn more about partnering with MidLantic Urology for your next urology trial.

Clinical Trials at MidLantic Urology

Clinical research trials play an essential role in bringing new treatments to our patients. Those who participate in trials enjoy the reassurance and security they get from being closely monitored, and the satisfaction that they are playing an important role in advancing medicine.

These clinical trials are currently available at MidLantic Urology.

Benign Prostatic Hyperplasia

PRODEON - EXPANDER-2 TRIAL

NCT05400980

A Randomized Study to Evaluate the Safety and Efficacy of the Urocross(TM) Expander System and Retrieval Sheath

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Bladder Cancer

JANSSEN BLC2001 - (SUNRISE 1)

NCT04640623

Phase 2b Clinical Study Evaluating Efficacy and Safety of TAR-200 in Combination with i. Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants with High-Risk Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette- ii. Guerin (BCG) who are Ineligible for or Elected Not to Undergo Radical Cystectomy

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JANSSEN BLC3001 - (SUNRISE 2)

NCT04658862

A Phase 3, Multi-center, Randomized Study Evaluating Efficacy of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-Invasive Urothelial Carcinoma (MIBC) of the Bladder who are not Receiving Radical Cystectomy

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JANSSEN SUNRISE-3

NCT05714202

A Phase 3, Open-Label, Multi-Center, Randomized Study Evaluating the Efficacy and Safety of TAR-200 in Combination with Cetrelimab Versus Intravesical BCG in Participants with BCG-naïve High-Risk Non-Muscle Invasive Bladder Cancer

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JANSSEN SUNRISE-4

NCT04919512

A Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder (SunRISe-4)

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JHU J18158

NCT03914794

Phase 2 Window of Opportunity Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients with Recurrent Low- or Intermediate-Risk Tumors

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MERCK 992

NCT04241185

This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with chemoradiotherapy (CRT) versus CRT alone in participants with muscle-invasive bladder cancer (MIBC). The primary hypothesis is that pembrolizumab + chemoradiotherapy is superior to placebo + chemoradiotherapy with respect to bladder intact event-free survival.

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MERCK KEYNOTE- 676

NCT03711032

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin in High-Risk Non-Muscle Invasive Bladder Cancer.

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THERALESE

NCT03945162

Intravesical Photodynamic Therapy (PDT) in BCG Refractory/Intolerant Non-Muscle Invasive Bladder Cancer (NMIBC) Patients

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Interstitial Cystitis

ABBVIE M21-459

NCT05141006

Study of BOTOX Injections to Assess Change in Disease Activity and Adverse Events in Adult Female Participants With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

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Prostate Cancer

ASTRAZENECA – CAPITELLO

NCT04493853

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency (CAPItello-281)

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CURIUM PHARMA - ECLIPSE

NCT05204927

Lu-177-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

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JANSSEN 3011 (PROTEUS STUDY)

NCT03767244

A Study of Apalutamide in Participants With High‑Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy (PROTEUS)

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Janssen 3015

NCT04557059

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Prostate-Specific Membrane Antigen-Positron Emission Tomography (PSMA-PET) Positive Hormone-Sensitive Prostate Cancer Participants (PRIMORDIUM).

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MLU2 - PROMISE

MLU3 - CHARTED (ANGLE – ANG-015)

NCT05437679

Characterization of Circulating Tumor Cells Isolated Using the Parsortix® System in High Risk and Early Metastatic Prostate Cancer Patients

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MSK: DOCETAXEL & RADIUM -223 (DORA STUDY)

NCT03574571

A Study to Test Radium-223 With Docetaxel in Patients With Prostate Cancer.

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Myovant 601-056

NCT05605964

Randomized Study to Evaluate MACE in Patients With Prostate Cancer Treated With Relugolix or Leuprolide Acetate (REPLACE-CV)

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PROPELLA THERAPEUTICS

NCT04729114

Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients With Advanced Prostate Cancer

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Renal Cell Carcinoma

MERCK - MK-022

NCT05239728

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

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For more information or to enroll in one of these trials, call MidLantic’s Clinical Research Department at 610-667-0458.

A Trusted Team

Clinical trials help scientists better understand disease and develop new medications, treatments, and devices. Our clinical research team is comprised of top physicians and specialists experienced in clinical research. We provide our patients with the opportunity to participate in clinical trials and gain access to the latest therapy and technology available to treat their urologic condition.

Led by Dr. Laurence Belkoff, D.O., F.A.C.O.S and Clinical Research Director Cheryl Zinar, RN, BSN, together oversee a dedicated research team of RNs, Research Assistants and Regulatory Specialists. Backed by a research committee of eight board certified physicians, we continually strive to advance urology health.